Where to buy ciprofloxacin

Ciprofloxacin-resistant strains and strains with reduced bacterial load are associated with reduced rates of morbidity and mortality. This study aimed to determine the efficacy of ciprofloxacin (Ciprodex) in the treatment of patients with chronic osteomyelitis (OOM) with reduced bacterial load.

Objectives

The primary objective of this study was to assess the impact of ciprofloxacin on the clinical outcome and to assess the effectiveness of the therapy.

Design

A randomized, double-blind study was conducted in 27 chronic osteomyelitis patients with an oral ciprofloxacin group (n = 18) and 20 control patients (n = 19) and a comparison group (n = 14) of non-antibiotic-treated patients.

The study population included all patients who were prescribed ciprofloxacin (Ciprodex) between October 2019 and December 2019.

Patients in both groups had at least one surgical procedure of osteomyelitis (e.g., bone graft, revision of the bone, and bone fusion). Patients in the Ciprodex-treated group had a mean weight of 22.0±12.8 kg, whereas patients in the control group had a mean weight of 22.0±12.3 kg.

The results of the study were:

  • Ciprofloxacin was found to have an effect on the clinical outcomes of patients with OOM with a significant reduction in the microbial load at 2 weeks when compared with the non-antibiotic group (P<0.001).
  • The rate of bacterial load reduction was higher in patients who received ciprofloxacin compared with the control group (P<0.05) and the proportion of bacterial load reduction was higher in patients with OOM (P=0.0007 and P<0.001).
  • The duration of the ciprofloxacin-treated group was significantly longer than the control group (p<0.05).

Conclusions

Ciprofloxacin had an overall positive effect in the clinical outcome of patients with OOM with reduced bacterial load. This study indicated that ciprofloxacin is an effective antibiotic in the treatment of OOM with a high rate of reduction of bacterial load in patients with a low bacterial load.

Citation:Boon T, Kuk H, Lee H, Park H, Lee M, Park Y. (2023) The Effect of Ciprofloxacin on the Clinical Outcomes of Patients with Chronic Osteomyelitis with Reduced Bacteroidetes and bacterial load.

Keywords:Ciprofloxacin, Ciprodex, OOM, Chronic osteomyelitis, OOM

Ciprofloxacin is a broad-spectrum antibiotic used for the treatment of infections caused by susceptible microorganisms. It is effective against a wide range of gram-positive and gram-negative microorganisms including staphylococci, Streptococci, Chlamydia and other bacteria.

The therapeutic effect of ciprofloxacin is mediated by inhibition of bacterial growth. It is commonly used to treat bacterial infections in patients with weakened immune systems and diseases. The mechanism of action of ciprofloxacin involves inhibiting the production of bacterial lipase, an enzyme that is involved in the degradation of drugs that interfere with bacterial growth.

Ciprofloxacin is a commonly used antibiotic in the treatment of bacterial infections. It is an inexpensive drug and is available for the treatment of bacterial infections in many countries. However, it is effective against a wide range of Gram-positive and Gram-negative microorganisms.

Indications

Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.

Administration

May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.

Contraindication

Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.

Common side-effects

Vomiting, Stomach pain, Nausea, Diarrhea

Special Precaution

Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.

Storage

Store between 20-25°C.

MedsGo Class

Quinolones

Hospital use after removal of corticosteroids or continuous ambulatory peritoneal dialysis

Molistero Class

Hepatic enzymes activity against ciprofloxacin; this may lead to its accumulation in the liver and in the renal impairment. Caution is advised in renal impairment. Elderly, patients with a history of blood disorders, renal impairment or hepatic impairment.

'' Special Precautions''

Patients with pre-existing pre-existing liver disease, kidney disease or renal impairment. Avoid contact with animals or close of urinary tract. Erythromycin may rarely cause neurological effects, including stereotypic behavior, hyperreflexia, retardancy, tremor, confusion and tingling or numbisation of hands, face, lips or any other area being sensitive to sunlight. Monitor magnesium, potassium, blood pressure and potassium levels. Monitor for signs of toxicity including evidence of lupus erythematosus, neutropenia, thrombocythemia, eosinophilia, suppressed platelets, jaundice, hepatic dysfunction and severe nausea, vomiting. Monitor for worsening of heart failure, decreased kidney function, renal impairment, hepatic venous or cardiac output and renal blood loss. Patients with a history of priapism or other allergic reactions to ciprofloxacin should seek medical advice promptly. Patients should avoid undertaking activities that cause pain, such as standing or walking, that require completeiazepine or selective serotonin reuptake inhibitors (SSRIs) such as ertines and oral corticosteroids for the treatment of pain, inflammation and itching. Ciprofloxacin should not be used by patients with a known sensitivity to ciprofloxacin. Very rare cases of priapism (prolonged and painful erection) have been reported with the use of quinolones, although these events have been reported in less than 1% of cases treated with these drugs in clinical practice. Patients should be advised to consult their primary doctor before receiving any treatment with quinolones. Discontinue ciprofloxacin if a prolonged treatment course with a drug other than quinolones leads to symptomatic cardiac effects is necessary.

Cipro XR 20mg Tablet is an antibiotic belonging to the fluoroquinolone class. It is used for the treatment of bacterial infections and certain other symptoms.

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Cipro XR 20mg Tablet may be taken on an empty stomach or with a meal. It should be strictly taken as advised by your doctor. The medicine will only help you to fight infections. It is very important to complete the full course of treatment prescribed by your doctor, even if you start feeling better. Never take it in larger or smaller amounts, but extra caution should be used to ensure that it is taken at the same time each day. Cipro XR 20mg Tablet should not be used in pregnant or breastfeeding women. Cipro XR 20mg Tablet should not be taken by children.

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Before using Cipro XR 20mg Tablet, let your doctor know if you have any liver, kidney or heart problems. Cipro XR 20mg Tablet is not recommended for use in children because it can harm the developing teeth and give you problems in the gums. Before using Cipro XR 20mg Tablet, let your doctor know if you are allergic to any medicines or have any medical conditions. Cipro XR 20mg Tablet should not be used in children as it can harm the developing teeth and give you problems in the gums.

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Cipro XR 20mg Tablet and pregnancy

Side effects of Cipro XR 20mg Tablet

Inform your doctor if you are pregnant or breastfeeding. Cipro XR 20mg Tablet may cause problems in the baby. It passes through breast milk. It is best to avoid it while you are pregnant, as it may harm the developing baby. Cipro XR 20mg Tablet is not recommended for use during breastfeeding because it can harm the developing baby. You should not take Cipro XR 20mg Tablet while you are breastfeeding because it can pass through breast milk.

It is important to inform your doctor if you are using any other medicines, including supplements and herbal medicines. Cipro XR 20mg Tablet is not recommended for use while you are using any other medicines, including any medicines. You should not take Cipro XR 20mg Tablet if you are taking any of the following medicines:

Riociguat

Riociguat is a medicine used to treat high blood pressure. It works by lowering blood pressure. Cipro XR 20mg Tablet is used to treat bacterial infections.

Cipro XR 20mg Tablet may cause diarrhea. If you experience any of the following symptoms, you should contact your doctor:

Common side effects of Cipro XR 20mg Tablet

Inform your doctor if you have any allergies, especially to fluoroquinolones, medicines, or any of the other ingredients of this medicine. Cipro XR 20mg Tablet is not recommended for use in children.

Cipro XR 20mg Tablet can harm the developing teeth and give you problems in the gums.

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